Renal sarcoidosis and hypercalcaemia
نویسنده
چکیده
Although the kidneys are infrequently involved in sarcoidosis, physicians involved in taking care of sarcoidosis patients need to be aware of this possibility in order to diagnose and treat this dangerous disorder before it causes serious damage. Sarcoidosis may either involve the kidneys directly or cause renal failure secondary to hypercalcaemia, hypercalciuria and nephrocalcinosis. Hypercalcaemia is an important complication of sarcoidosis. It is caused by overproduction of 1,25-dihydroxyvitamin D3 (calcitriol or calcitriol) by activated macrophages and the granulomatous tissue. Calcitriol, in turn, causes increased absorption of calcium from the gut. Hypercalcaemia is not specific to sarcoidosis as it is found in other granulomatous, as well as nongranulomatous, disorders, including tuberculosis, coccidioidomycosis, histoplasmosis, leprosy and Wegener’s granulomatosis.
منابع مشابه
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